Andie MacDowell modeled for Vogue magazine and appeared in ad campaigns for Yves Saint Laurent, Vassarette, Armani perfume, Sabeth-Row, Mink International, Anne Klein and Bill Blass in 1980. She worked with such esteemed photographers as Bruce Weber, Richard Avedon, Helmut Newton, Irving Penn and Herb Ritts among others.
The Legend of Tarzan, Lord of the Apes, a role in which her lines were recorded by Glenn Close because her southern accent was too pronounced for her to play the role of an Englishwoman. In 1985, she had a small part in St. Elmo's Fire.
Her performance earned her an Independent Spirit Award, a Los Angeles Film Critics Association Award for Best Actress, several other award nominations and led to a series of starring roles in films such as Green Card, The Object of Beauty, and Short Cuts.
Four Weddings and a Funeral (1994), opposite Hugh Grant. Groundhog Day and Four Weddings and a Funeral remain MacDowell's biggest box office hits.MacDowell appears in print and television advertisements for the cosmetic and haircare company L'Oréal.